Description
TYLOSIN-200 for injection
(solution for injection)
Description
A transparent solution from yellowish to dark yellow.
Composition
1 ml of the preparation contains the active substance:
tylosin (as tylosin tartrate) – 200 mg.
Excipients: propylene glycol, benzyl alcohol, water for injections.
Pharmacological properties
АТСvet QJ01, antibacterial veterinary preparations for systemic use (QJ01FA90, tylosin)
Tylosin is a macrolide antibiotic active against gram-negative (Bacteroides nodosus, Moxarella bovis, Neisseria spp., Pasteurella spp., Spirochetes spp.) and gram-positive (Erysipelothrix rhusiophathiae, Staphylococcus spp., Streptococcus spp., Diplococcus spp., Corynebacterium spp., Clostridium spp.) microorganisms. Especially sensitive to mycoplasmas (Mycoplasma gallisepticum, M. hyopneumoniae, M. synoviae, M. meleagridis, M. agalactiae, M. bovigenitalium), chlamydia (Chlamydia spp.) and rickettsia (Rickettsia spp.).
The mechanism of action of tylosin is binding to the peptidyl transferase 50S of the ribosomal subunit of drug-sensitive bacteria, which leads to inhibition of protein synthesis. Tylosin acts bacteriostatically, and in high concentrations – bactericidal.
After intramuscular injection, tylosin is unevenly distributed in tissues, but enters the cells of all organs and biological fluids, penetrates through the placental barrier and into milk. The maximum concentration of tylosin in the blood serum is noted after 0.5-1 hour and is maintained for 6-8 hours, the therapeutic concentration is up to 24 hours. Tylosin, after passing through the cytoplasmic membrane into the cell, interacts with receptors, which leads to a change in intracellular metabolism towards anabolism or catabolism, depending on the dose. Tylosin is metabolized mainly in the liver, excreted mainly in the urine and bile, as well as in milk.
Usage
Cattle: treatment of animals with pneumoenteritis, diphtheria, necrotizing pododermatitis, metritis, mastitis, arthritis, as well as respiratory diseases caused by microorganisms sensitive to tylosin
Sheep, goats: treatment of animals with bronchopneumonia, pneumonia, pleuropneumonia, contagious agalactia, chlamydial miscarriage, mycoplasmic arthritis caused by microorganisms sensitive to tylosin
Pigs: treatment of animals with enzootic bronchopneumonia, dysentery, leptospirosis, MMA syndrome, atrophic rhinitis, mycoplasmic and staphylococcal arthritis caused by microorganisms sensitive to tylosin.
Dosage
Intramuscular dose:
cattle – 2.5 ml of the preparation per 100 kg of body weight (which corresponds to 5 mg of tylosin per 1 kg of body weight) once a day;
sheep, goats – 0.5 ml of the preparation per 10 kg of body weight (which corresponds to 10 mg of tylosin per 1 kg of body weight) once a day;
pigs – 0.5-0.6 ml of the preparation per 10 kg of body weight (which corresponds to 10-12 mg of tylosin per 1 kg of body weight) once a day.
Treatment should continue for at least 24 hours after the disappearance of the symptoms of the disease, but not more than 5 days.
Contraindications
Do not administer to animals with hypersensitivity to tylosin, as well as animals with impaired liver function.
Do not administer to horses (treatment may be lethal).
Do not use during vaccination.
Do not use intravenously. Do not administer to animals with impaired liver function.
Do not use simultaneously with penicillin, cephalosporins, and lincomycin due to a pronounced decrease in the antibacterial effect of tylosin.
Cautions
Side effects
Hypersensitivity reactions are possible. At the injection sites, pain and temporary swelling are possible.
Epigastric pain, vomiting, diarrhea, anorexia.
In pigs, there is swelling of the rectal mucosa with protrusion, itching, erythema, and diarrhea.
Special cautions for use
Before using the preparation, it is necessary to do a test for the sensitivity of the pathogen to tylosin.
If the dose of the preparation during injection exceeds 10 ml for cattle, 5 ml for pigs, sheep, and goats, then the injection volume is divided into two parts and injected into different places.
Do not use the preparation simultaneously with other preparations for injection (possible precipitation of active substances).
Use during pregnancy, lactation, egg production.
The preparation for pregnant animals is used only when the benefits outweigh the risks.
Interaction with other means and other forms of interaction
The interaction of the preparation with spiramycin and tetracycline is synergetic.
The preparation is compatible with sulfonamides, nitrofurans, chloramphenicol, erythromycin, and spectinomycin.
Do not use simultaneously with penicillin, cephalosporins and lincomycin due to a pronounced decrease in the antibacterial effect of tylosin.
Withdrawal period
Slaughter of animals for meat is allowed after 28 days (cattle), 14 days (pigs), and 42 days (sheep, goats) after the last use of the preparation. The use of milk is allowed 4 days after the last use of the preparation. Meat and milk received before the specified time is disposed of or fed to unproductive animals, depending on the conclusion of a veterinarian.
Packaging
10, 50 and 100 ml glass bottles, closed with rubber stoppers under aluminum caps.
Storage conditions
Dry, dark place, out of the reach of children, at a temperature of 5 to 25 oС.
Shelf life
2 years.
After the first selection from the bottle, the preparation must be used within 28 days if stored in a dark place at a temperature of 2 °C to 8 °C.